New Pill For Type 2 Diabetes Treatment

A new pill is currently being used and marketedin the UK to help lower down A1C level..and it seemed to be working, according to the findings.

Please read the whole article below.

New Pill For Type 2 Diabetes Enhances Patients' Natural Body Process To Improve Blood Sugar
Vildaglip

Article Date: 24 Apr 2008 - 3:00 PDT

Vildagliptin, a new oral treatment for patients with type 2 diabetes is now available in the UK. Vildagliptin demonstrated additional reductions in HbA1c of 1.1% versus placebo when added to metformin1. In metformin treated patients with a baseline HbA1c over 9% the addition of Vildagliptin reduced HbA1c by an additional 1.5%2.

As reported in the United Kingdom Prospective Diabetes Study (UKPDS) which assessed conventional antidiabetic therapies, every 1% reduction in HbA1c is important as it reduces the risk of diabetes related death by 21%, heart attack by 14% and microvascular complications by 37%3. One in 3 patients on metformin monotherapy continue to have uncontrolled diabetes (>7.5% HbA1c)4.

Weight gain is a common side effect of traditional add-on type 2 diabetes therapies5,6,7. Unlike thiazolidinediones (glitazones) and sulphonylureas, Vildagliptin in combination with metformin has a neutral effect on mean body weight in clinical trials and, in contrast to sulphonylureas, is associated with a low incidence of hypoglycaemia1,5,6,8,9. In addition, when added to metformin in clinical studies, Vildagliptin has an overall gastrointestinal side effect profile that is comparable to placebo1,9.

"Around 80% of people diagnosed with type 2 diabetes are overweight and it is a real concern that the treatments they need to take to control their blood sugar can lead to added weight gain or other harmful side effects" said Dr Eugene Hughes, GP, Isle of Wight. "As an effective treatment without weight gain when used in combination with metformin in clinical trials, Vildagliptin offered a potential solution to this very real problem."

Vildagliptin targets islet cell dysfunction, helping to restore the body's natural ability to increase insulin and decrease glucagon - the two main hormones controlling blood sugar levels10. Vildagliptin has a glucose sensitive mode of action; when blood glucose levels rise, Vildagliptin enhances the appropriate production of insulin by the pancreatic beta cells and decreases inappropriate production of glucagon by pancreatic alpha cells, resulting in improved glycaemic control11,12. Most other classes of type 2 diabetes medicines work by targeting either insulin resistance or stimulating insulin secretion11-13.

Vildagliptin is the only DPP-4 (dipeptidyl-peptidase IV) inhibitor available both alone and in a combination tablet with metformin. Used together, Vildagliptin and metformin address the two major causes of type 2 diabetes - islet dysfunction and insulin resistance10,13.

Dr Marc Evans, Consultant Diabetologist, Llandough Hospital, Cardiff, highlights the importance of this advance: "Vildagliptin helps the body respond appropriately to blood glucose levels. It offers a promising treatment for the significant proportion of patients whose blood sugar levels are above target levels and are therefore at risk of microvascular and macrovascular complications"

About Vildagliptin

Vildagliptin has been studied extensively in over 10,000 patients worldwide across diverse patient populations including patients of different ethnicity and varying age groups.

Vildagliptin is expected to be prescribed mainly for:

· dual oral therapy in combination with metformin, in patients with insufficient glycaemic control despite on maximal tolerated dose of monotherapy with metformin9But also has a license for use in9:

· dual oral therapy in combination with a sulphonylurea, where patients with insufficient glycaemic control despite maximal tolerated dose of a sulphonylurea and for whom metformin is inappropriate due to contraindications or intolerance· dual oral therapy with a glitazone in patients with insufficient glycaemic control and for whom the use of a glitazone is appropriate

Vildagliptin is marketed in the UK by Novartis Pharmaceuticals UK Ltd.


(Source: http://www.medicalnewstoday.com/articles/105194.php)